As if the onset of Diabetes Mellitus was not enough of a trial, insulin sensitive type 2 diabetics have had a hard time keeping their glycemic index at a healthy level.
So far, there was no alternative to insulin, but now there is hope for the insulin sensitive diabetic.
Researchers at the Washington University School of Medicine approached the problem from a different angle. They decided to strike the problem close to its root. The research is published online in Cell Metabolism.
Instead of remedying the situation after the deed was done, they looked around to see if they could reduce the production of sugar itself. The study has succeeded on mice but is not yet tested on humans.
Our liver produces the body sugars. It uses a protein to make this sugar. They decided to attempt to slow down the production of sugar in the liver. They worked on mice and showed that they could reduce glucose production in the liver and lower blood sugar levels.In mice, they succeeded in shutting down the liver protein by which glucose was made. If the method works on humans, this could be a boon to patients with type 2 diabetes.
Brian N. Finck, Principal investigator in the study thinks that a drug that shuts down glucose production has the potential to help millions of people affected by the most common form of diabetes mellitus and could lead to more effective drugs for type 2 diabetes.
This research regarding interference with pyruvate transport could also bring help to persons with non-alcoholic fatty liver disease, a condition common in people with obesity.
Diabetics would therefore be benefitted twice over. One, in the management of their glycemic index and second, by a reduction of obesity which is one of the prevalent causes of diabetes mellitus.
E65 – Diabetes Mellitus May Not Be So Dependent on Insulin, After all – www.diabetic.today
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