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New Development. Diabetes Mellitus Linked To Inflammation Caused By Obesity.

Endoplasmic Reticulum
Endoplasmic Reticulum
Researchers have found a fresh connection between obesity and development of type 2 diabetes — Inflammation related to obesity and endoplasmic reticulum dysfunction.
Endoplasmic reticulum is a mini-organ inside cells that plays a key role in the synthesis of many proteins and lipids. Consequently, it helps maintain proper glucose levels in the body and is therefore, very important for the health of the liver and other organs which are known to be involved in the development of Type 2 Diabetes mellitus.
Nitrogen Oxide
Nitrogen Oxide
Harvard T.H. Chan School of Public Health believes that this connection could be used to help develop new therapies for curbing diabetes.
The research study of liver cells showed that obesity-associated inflammation led to increased production of nitric oxide. This potent gas could cause endoplasmic reticulum dysfunction.
Obesity and the causes of obesity interferes with the endoplasmic reticulum’s ability to create Unfolded Protein Response (a series of intracellular events). This response relieves endoplasmic reticulum stress and restores its ability to function well.
Nitrogen Oxide
We can dia-beat-this!

 

Senior author Gokhan S. Hotamisligil warns that it is possible that it is obesity-related inflammation that impairs the Unfolded Protein Response and thus impairs endoplasmic reticulum function.
He explains that the study results establish that, in an environment of chronic inflammation, mini organs lose their vitality through a specific link that they were able to identify in their study.  According to him, therapies that target inflammatory pathways (including nitric oxide production), could be effective in the treatment of metabolic diseases like diabetes.
The researchers used an innovative approach and engineered a form of IRE1 that nitric oxide could not modify. They studied the effect of this on mice and found that this IRE1 protected against the detrimental consequences of inflammation and improved metabolic control in obese mice.
E82 – Diabetes Mellitus Linked To Inflammation Caused By Obesitywww.diabetic.today
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