Alpha lipoic acid (ALA) is a natural molecule consisting of a five-membered cyclic disulphide and hydrocarbon tail ending with a carboxylic acid group. Hence, lipoic acid is a predominantly lipophilic molecule having an amphipathic character due to its carboxylic acid group attached to the ring structure.
Lipoic acid is present in our diet mainly in animal foods such as meat and liver and at low or undetectable levels in plant foods such as potato. However, lipoic acid is also considered beneficial when used as a food supplement as its antioxidant function has been previously reported and several studies have revealed its protective effects in cases such as aging, diabetes mellitus, vascular and neurodegenerative diseases all in which free radicals are involved.
Studies are generally dealing with the biological consequences of lipoic acid administration in cases associated with oxidative stress or the differences between 65 the antioxidant activities of lipoic acid and its derivatives. There are also some studies on the spectroscopic and chromatographic analysis of the structural and quantitative aspects of lipoic acid and its derivatives in solution125.
However, structural information on the exact mode of interaction of lipoic acid with molecules of biological systems is lacking, despite the fact that investigation of the interactions of antioxidative drugs with biomolecules is important in understanding the mechanism of their action.
Alpha Lipoic Acid, because of its antioxidant properties, α-lipoic acid has been tested as a possible therapeutic agent in many common diseases like diabetes.
E239 – Antioxidant Benefits of Alpha Lipoic Acid– www.diabetic.today