Researchers have found a fresh connection between obesity and development of type 2 diabetes — Inflammation related to obesity and endoplasmic reticulum dysfunction.
Endoplasmic reticulum is a mini-organ inside cells that plays a key role in the synthesis of many proteins and lipids. Consequently, it helps maintain proper glucose levels in the body and is therefore, very important for the health of the liver and other organs which are known to be involved in the development of Type 2 Diabetes mellitus.
Harvard T.H. Chan School of Public Health believes that this connection could be used to help develop new therapies for curbing diabetes.
The research study of liver cells showed that obesity-associated inflammation led to increased production of nitric oxide. This potent gas could cause endoplasmic reticulum dysfunction.
Obesity and the causes of obesity interferes with the endoplasmic reticulum’s ability to create Unfolded Protein Response (a series of intracellular events). This response relieves endoplasmic reticulum stress and restores its ability to function well.