Different cows, basically, have different proportions of the A1 and A2 beta-casein, which are different proteins.
The Guernsey cow, the older cows, have the original premium retailed form of the A2 beta-casein, whereas the Holstein cow have the A1 beta-casein in high proportion.
Studies are talking about a strong co-relation, but more trials need to be done, needing to compare disease risks of A1-free versus ‘ordinary’ milk.
Research into cow’s milk, in particular Casein – the A1 beta-casein — one of the proteins found in milk has shown negative health effects particularly, heart disease and diabetes. There are other health effects being studied and it supports some correlation.
In milk, one of the main proteins is Casein which is about 76% – 86% of the milk and whey-protein makes up about 20%. This 80% is arranged in the casein as micelles which are basically little globules. They arrange themselves in solution cords. The outer-part of the micelles are negatively charged. There is a Hydrophillic head and a hydrobhobic tail and these form clumps.
There are two basic strains – A1 beta-casein and A2 beta-casein. The A1 is a newer protein chain. There’s been mutation in some cows during the breeding process because they introduced some protein – one amino acid difference at position 67 in the protein chain – in the original protein, from the original cow and this protein has a very strong connection to the rest of the chain.
In the histidine, the attraction is not so strong to the rest of the chain. This in the digestion process is BCM7 which can easily break off during the digestive process and that is an opiod that can be absorbed in through the gut and hence some of the health effects.
A healthy gut should be very good at controlling which macro-molecules do get through into the blood stream but with a leaky gut, which is a result of different things, young babies have a more transmissive gut so they could be more susceptible, or if you’ve had an infection, the toxic disruption could cause some inflammation and increased transmission of these macro-molecules allowing this BCM7 to get through.
There is co-relation, particularly if you have a healthy gut, the amount of BCM7 getting through will be definitely reduced so the effects might not be there but if you’ve got high-transmission that could be quite bad. In other studies, there has been no evidence established between A1 and A2 milk and diabetes, CHD or other diseases.
More research is required but preliminarily there is some sort of correlation between A1 being a bit of a bad mutated form of the protein that is probably been introduced during the breeding process, getting the cows genetically suited for mass milking — it could even have been thousands of years ago.
E219 – A1 and A2 – betacasein Milk and Diabetes – www.diabetic.today