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Iron Overload and Diabetes

Not only predicted but expected
Can iron deficiency cause diabetes?

Too much iron can be as bad as too little. The gradual build-up of iron levels in the body over many years is a hereditary condition known as haemochromatosis. It’s one of the most common genetic disorders and affects around one in 200 people especially those from a Celtic/ European background. The faulty gene causes us to absorb twice as much iron as we need. This much extra iron is thought to increase free radical chemicals in the body, linked to ageing and many diseases. The excess builds up gradually from childhood, so symptoms take years to appear often in our thirties or forties, or even later in women, as we lose some iron in our periods.

The genes

How does hemochromatosis affect the pancreas?

In 90 percent of cases, the HFE gene is to blame, but other mutations are sometimes involved. You won’t develop haemochromatosis unless you get two doses of the faulty gene, one from each parent. A single dose means you’re a carrier, with a one in two chance of passing on that single dose. If your partner is a carrier too, your children have a one in four chance of getting the double dose.

Symptoms for haemochromatosis

What causes bronze diabetes?

These come on slowly and may seem vague at first, or resemble other medical conditions that affect us from midlife onwards. Early symptoms include feeling constantly tired, joint pains, weight loss and irregular or absent periods. As the deposits increase in your skin, you may develop a permanent tan. In other organs, however, these deposits can produce serious complications. Your liver may develop scarring and stop working properly, which can lead to cirrhosis or, in rare cases, cancer. You’ll notice tummy pain, nausea, jaundice (yellow eyes and skin) and itching. As your pancreas becomes affected, you may develop high blood sugar and diabetes. Joints feel stiff and painful and heart muscle damage may lead to heart failure with chest pain, breathlessness, ankle swelling and palpitations. Men develop erection problems, and both sexes lose their libido.

The treatment

Can hemochromatosis cause diabetes?

This involves removing iron from your body. It’s like giving a 500ml blood donation, weekly at first, then every two months or so. If this isn’t effective, you may be prescribed chelation therapy (tablets to make you excrete iron). Many of your symptoms will improve, but you may need : treatment for diabetes, heart failure or other complications. You’ll need to avoid iron, Vitamin C supplements and fortified cereals containing iron. Your doctor may also advise against drinking tea, coffee and alcohol with meals, as well as avoiding iron rich foods (red meat, liver, kidneys) and raw shellfish.

Five Tests You May Need

  1. Blood tests for high levels of iron in the blood (transferrin saturation) and body (ferritin), and to see how your pancreas, liver and organs are working.
  2. Checks for other causes of iron build-up (iron supplements, blood transfusions, kidney dialysis, liver disorders and other conditions that affect how the body handles iron).
  3. Ultrasound and/or MRI scans to see how various organs/tissues are affected.
  4. Liver biopsy (small tissue sample taken using local anaesthetic) to assess damage and look for any liver conditions.
  5. Blood tests for faulty genes. Relatives may need to be tested too – the earlier treatment is started, the better.

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